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Endocrine Abstracts

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ea0092ps2-20-06 | Thyroid hormone receptors basic | ETA2023

A cardiac developmental defect prevents thyroid hormone-induced tachycardia in the syndrome of resistance to thyroid hormone alpha

Dore Riccardo , Christine Sentis Sarah , Oelkrug Rebecca , Krause Christin , Geiszler Cathleen , Pedaran Mehdi , Kirchner Henriette , Mittag Jens

Objectives: Thyroid hormones (TH) affect cardiovascular functions via direct actions on the heart and via indirect actions on central nervous system. Mutations in TH receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.Methods: The current experiments aimed at investigating the role of peripheral and central TR&...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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